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Alpha-2 adrenergic receptor : ウィキペディア英語版 | Alpha-2 adrenergic receptor
The alpha-2 (α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein. It consists of three highly homologous subtypes, including α2A-, α2B-, and α2C-adrenergic. Some species other than humans express a fourth α2D-adrenergic receptor as well. Catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) signal through the α2-adrenergic receptor in the central and peripheral nervous systems. == Cellular localisation == α2A adrenergic receptor is localised in the following central nervous system (CNS) structures: * Brainstem (especially the locus coeruleus) * Midbrain * Hypothalamus * Hippocampus * Spinal cord * Cerebral cortex * Cerebellum * Septum Whereas the α2B adrenergic receptor is localised in the following CNS structures:〔 * Olfactory system * Thalamus * Pyramidal layer of the hippocampus * Cerebellar purkinje layer and the α2C adrenergic receptor is localised in the CNS structures:〔 * Midbrain * Thalamus * Amygdala * Dorsal root ganglia * Olfactory system * Hippocampus * Cerebral cortex * Basal ganglia * Substantia nigra * Ventral tegmentum
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