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Alpha-2 adrenergic receptor
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Alpha-2 adrenergic receptor : ウィキペディア英語版
Alpha-2 adrenergic receptor

The alpha-2 (α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein. It consists of three highly homologous subtypes, including α2A-, α2B-, and α2C-adrenergic. Some species other than humans express a fourth α2D-adrenergic receptor as well. Catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) signal through the α2-adrenergic receptor in the central and peripheral nervous systems.
== Cellular localisation ==
α2A adrenergic receptor is localised in the following central nervous system (CNS) structures:
* Brainstem (especially the locus coeruleus)
* Midbrain
* Hypothalamus
* Hippocampus
* Spinal cord
* Cerebral cortex
* Cerebellum
* Septum
Whereas the α2B adrenergic receptor is localised in the following CNS structures:〔
* Olfactory system
* Thalamus
* Pyramidal layer of the hippocampus
* Cerebellar purkinje layer
and the α2C adrenergic receptor is localised in the CNS structures:〔
* Midbrain
* Thalamus
* Amygdala
* Dorsal root ganglia
* Olfactory system
* Hippocampus
* Cerebral cortex
* Basal ganglia
* Substantia nigra
* Ventral tegmentum

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Alpha-2 adrenergic receptor」の詳細全文を読む



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